Set in the near future, weapons master James McCullen creates a warhead capable of destroying cities, and soon after he sells four of the lethal warheads to NATO. American soldiers Duke (Channing Tatum) and Ripcord (Marlon Wayans) lead a small team to deliver them. But their convoy is ambushed by the Baroness (Sienna Miller), and the soldiers only narrowly escape with the aid of G.I. Joe members Scarlett, Snake Eyes, Breaker, and Heavy Duty. The group takes the warheads to “The Pit” and rendezvous with the head of the G.I. Joe Team, General Hawk (Dennis Quaid) who takes command of the warheads and continues their mission to protect and deliver them.